012 Treg dysfunction induces autoantibodies to type XVII collagen and BP230 in mice and humans

Pemphigoid in Mice Type XVII Collagen and Leads to Bullous Repetitive Immunization Breaks Tolerance to

: metadiscourse in introduction sections of applied linguistics and physics research articles: exploring variation in frequency and type

abstract in written mode of language, metadiscourse markers are used commonly to help writers in general and academic writers in particular to produce coherent and professional texts. the purpose of the present study was to compare introduction sections of applied linguistics and physics articles regarding their use of interactive and interactional metadiscourse markers based on the model pro...

Passive transfer of collagen XVII-specific antibodies induces sustained blistering disease in adult mice

BACKGROUND Bullous pemphigoid is a subepidermal blistering disorder associated with tissue-bound and circulating autoantibodies directed mainly to the hemidesmosomal component collagen XVII. While recapitulating the main immunopathological features of the human disease, frank skin blistering does not develop in the absence of skin rubbing in experimental pemphigoid models that have been establi...

incidence of microscopic lumbar intervertebral disc calcification and its correlation to endplate degeneration type and disc histopathologic angiogensis

چکیده ندارد.

Type XVII collagen coordinates proliferation in the interfollicular epidermis

Type XVII collagen (COL17) is a transmembrane protein located at the epidermal basement membrane zone. COL17 deficiency results in premature hair aging phenotypes and in junctional epidermolysis bullosa. Here, we show that COL17 plays a central role in regulating interfollicular epidermis (IFE) proliferation. Loss of COL17 leads to transient IFE hypertrophy in neonatal mice owing to aberrant Wn...